CD22 anticorps

N° du produit ABIN135163

Cet anticorps Rat Monoclonal détecte spécifiquement CD22 dans FACS, IP, ICC, IHC (p), IHC (fro) et Act. Il présente une réactivité avec des échantillons de Souris.

Aperçu rapide pour CD22 anticorps (ABIN135163)

Antigène: CD22 (CD22 Molecule (CD22))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD22 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Activation (Act)

Clone: 2D6

Détail du produit anti-CD22 anticorps

Fonction: Rat Anti-Mouse CD22-LE/AF

Specificité: Mouse CD22, Mr 150 kDa

Attributs du produit: Low Endotoxin/Azide Free Anti-Mouse CD22 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, and activation assays.

niveau d'endotoxine: Low Endotoxin

Immunogène: Splenic lymphocyte plasma membranes from CBA x C57 F1 mice

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Agent conservateur: Azide free

Conseil sur la manipulation: Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: 2-8°C

Détails sur CD22

Antigène: CD22 (CD22 Molecule (CD22))

Autre désignation: CD22

Sujet: CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B-cell activation.

ID gène: 12483

UniProt: P35329