CD40 anticorps

N° du produit ABIN135211

Cet anticorps Rat Monoclonal détecte spécifiquement CD40 dans FACS. Il présente une réactivité envers Souris et a été mentionné dans 1 publication.

Aperçu rapide pour CD40 anticorps (ABIN135211)

Antigène: CD40

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD40 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: 1C10

Détail du produit anti-CD40 anticorps

Specificité: Mouse CD40, Mr 45-50 kDa

Attributs du produit: Rat Anti-Mouse CD40-UNLB

Purification: Purified

Immunogène: sCD40

Isotype: IgG2a

Information d'application

Indications d'application:

• Applications: FC - Quality tested , IP - Reported in literature , Activ - Reported in literature , Block - Reported in literature
• Working Dilutions: Flow Cytometry FITC and BIOT conjugates 2 g/106 cells PE, APC, and SPRD conjugates 0.5 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L

Commentaires:

In vitro induction of proliferation of mature B lymphocyte

Volume d'échantillon: 1 mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: 0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Agent conservateur: Without preservative

Conseil sur la manipulation: Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C

Références pour anticorps anti-CD40 (ABIN135211)

Duarte, Cragnolini, Swee, Bilate, Bader, Ingram, Rashidfarrokhi, Fang, Schiepers, Hanke, Ploegh: "Generation of Immunity against Pathogens via Single-Domain Antibody-Antigen Constructs." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 12, pp. 4838-4847, (2017) (PubMed).

Détails sur CD40

Antigène: CD40

Autre désignation: CD40

Sujet: CD40 is a type I cell surface protein belonging to the tumor necrosis factor superfamily of cell surface receptors. In mice it is expressed on B lineage cells, follicular dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zone of secondary lymphoid organs. CD40 first becomes detectable on a subset of small pre-B II cells in bone marrow, with the levels of CD40 expression increasing thereafter during B-cell maturation. Immature B cells (IgM+IgDloB220lo) express intermediate levels of CD40, whereas mature B cells (IgM+IgDhiB220hi) express high levels. CD40 has a central role in B cell growth and differentiation, and signalling through CD40 in combination with IL-4 reportedly induces immunoglobulin isotype switching and secretion of IgE.

Pathways: Signalisation NF-kappaB, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints