CD40 anticorps

N° du produit ABIN135214

Cet anticorps Rat Monoclonal détecte spécifiquement CD40 dans FACS, IP, BR et Act. Il présente une réactivité avec des échantillons de Souris.

Aperçu rapide pour CD40 anticorps (ABIN135214)

Antigène: CD40

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD40 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Blocking Reagent (BR), Activation (Act)

Clone: 1C10

Détail du produit anti-CD40 anticorps

Fonction: Rat Anti-Mouse CD40-LE/AF

Specificité: Mouse CD40, Mr 45-50 kDa

Attributs du produit: Low Endotoxin/Azide Free Anti-Mouse CD40 antibody for use in flow cytometry, immunoprecipitation, activation, and blocking assays.

niveau d'endotoxine: Low Endotoxin

Immunogène: sCD40

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Agent conservateur: Azide free

Conseil sur la manipulation: Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: 2-8°C

Détails sur CD40

Antigène: CD40

Autre désignation: CD40

Sujet: CD40 is a type I cell surface protein belonging to the tumor necrosis factor superfamily of cell surface receptors. In mice it is expressed on B lineage cells, follicular dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zone of secondary lymphoid organs. CD40 first becomes detectable on a subset of small pre-B II cells in bone marrow, with the levels of CD40 expression increasing thereafter during B-cell maturation. Immature B cells (IgM+IgDloB220lo) express intermediate levels of CD40, whereas mature B cells (IgM+IgDhiB220hi) express high levels. CD40 has a central role in B cell growth and differentiation, and signalling through CD40 in combination with IL-4 reportedly induces immunoglobulin isotype switching and secretion of IgE.

ID gène: 21939

UniProt: P27512

Pathways: Signalisation NF-kappaB, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints