CTLA4 anticorps

N° du produit ABIN135318

Détail du produit anti-CTLA4 anticorps

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reactivité: Souris

Hôte: Hamster

Clonalité: Monoclonal

Conjugué: Cet anticorp CTLA4 est non-conjugé

Application: ELISA

Specificité: Mouse CD152, Mr 33-37 kDa

Attributs du produit: Hamster Anti-Mouse CD152-UNLB

Purification: Purified

Immunogène: Heat-killed Staphylococcus A bacteria coated with mouse CTLA-4/human IgG1 fusion protein

Clone: 9H10

Isotype: IgG

Information d'application

Indications d'application:

• Applications: ELISA - Quality tested , FC - Reported in literature , IP - Reported in literature , Costim - Reported in literature , Block - Reported in literature
• Working Dilutions: ELISA Purified (UNLB) antibody 1 g/mL

Commentaires:

In vitro and in vivo blocking of CTLA-4 action by soluble antibody, Promotion of in vitro CTLA-4 signaling by cross-linked antibody

Volume d'échantillon: 1 mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: 0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Agent conservateur: Without preservative

Conseil sur la manipulation: Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C

Détails sur CTLA4

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Autre désignation: CD152 (CTLA4 Produits)

Synonymes: anticorps CTLA-4, anticorps CTLA4, anticorps CD152, anticorps Cd152, anticorps Ctla-4, anticorps Ly-56, anticorps CD, anticorps CELIAC3, anticorps GRD4, anticorps GSE, anticorps IDDM12, anticorps sCTLA4, anticorps cytotoxic T-lymphocyte associated protein 4, anticorps cytotoxic T-lymphocyte-associated protein 4, anticorps CTLA4, anticorps Ctla4

Sujet: CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28. Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80/B7-1 and CD86/B7-2) on antigen-presenting cells. CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T-cell stimulation via the T cell receptor (TCR) complex. Whereas CD28 provides a positive costimulatory signal, CD152/CTLA-4 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signalling through the TCR through its association with tyrosine phosphatases such as SHP-2.

Pathways: Cancer Immune Checkpoints