CTLA4 anticorps

N° du produit ABIN135319

Cet anticorps Hamster Monoclonal détecte spécifiquement CTLA4 dans FACS, ELISA, IP, BR et CoSt. Il présente une réactivité avec des échantillons de Souris.

Aperçu rapide pour CTLA4 anticorps (ABIN135319)

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reactivité: Souris

Hôte: Hamster

Clonalité: Monoclonal

Conjugué: Cet anticorp CTLA4 est non-conjugé

Application: Flow Cytometry (FACS), ELISA, Immunoprecipitation (IP), Blocking Reagent (BR), Co-Stimulation (CoSt)

Clone: 9H10

Détail du produit anti-CTLA4 anticorps

Fonction: Hamster Anti-Mouse CD152-LE/AF

Specificité: Mouse CD152, Mr 33-37 kDa

Attributs du produit: Low Endotoxin/Azide Free Anti-Mouse CD152 antibody for use in flow cytometry, ELISA, blocking, and costimulation assays.

niveau d'endotoxine: Low Endotoxin

Immunogène: Heat-killed Staphylococcus A bacteria coated with mouse CTLA-4/human IgG1 fusion protein

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Agent conservateur: Azide free

Conseil sur la manipulation: Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: 2-8°C

Détails sur CTLA4

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Autre désignation: CD152

Sujet: CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28. Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80/B7-1 and CD86/B7-2) on antigen-presenting cells. CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T-cell stimulation via the T cell receptor (TCR) complex. Whereas CD28 provides a positive costimulatory signal, CD152/CTLA-4 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signalling through the TCR through its association with tyrosine phosphatases such as SHP-2.

ID gène: 12477

UniProt: P09793

Pathways: Cancer Immune Checkpoints