PKM2 anticorps (pSer37)

N° du produit ABIN1355883

Cet anticorps anti-PKM2 est un anticorps Lapin Polyclonal détectant PKM2 dans WB. Adapté pour Humain. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour PKM2 anticorps (pSer37) (ABIN1355883)

Antigène: PKM2 (Pyruvate Kinase M2 (PKM2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKM2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PKM2 anticorps

Épitope: pSer37

Specificité: The antibody detects endogenous level of PKM2 only

Immunogène: Peptide sequence around phosphorylation site of pSer37 (I-D-S (p) -P-P) derived from Human PKM2.

Information d'application

Indications d'application: Western Blot: 1:500-1000  

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: 4 °C/-20 °C

Références pour anticorps anti-PKM2 (ABIN1355883)

Yang, Zheng, Xia, Ji, Chen, Guo, Lyssiotis, Aldape, Cantley, Lu: "ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect." dans: Nature cell biology, Vol. 14, Issue 12, pp. 1295-304, (2012) (PubMed).

Détails sur PKM2

Antigène: PKM2 (Pyruvate Kinase M2 (PKM2))

Autre désignation: PKM2

Sujet: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Poids moléculaire: 60 kDa

Pathways: L'effet Warburg