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PKM2 anticorps (pSer37)

Name: PKM2 anticorps (pSer37)
SKU: ABIN1355883
Price: 408.4 EUR
Availability: InStock

PKM2 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated

(1 reference)

N° du produit ABIN1355883

Fiche de données

Antigène Voir toutes PKM2 Anticorps

PKM2 (Pyruvate Kinase M2 (PKM2))
Épitope
16

15

15

12

7

7

7

7

7

6

6

5

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer37
Reactivité
141

99

87

4

4

2

2

2

2

2

1

1

1
Humain
Hôte
121

21

4
Lapin
Anticorps secondaires appropriés
Clonalité
126

20
Polyclonal
Conjugué
55

12

10

10

10

10

10

10

3

3

2

2

2

2

2

2

1
Cet anticorp PKM2 est non-conjugé
Application
84

32

27

27

23

19

15

11

9

7

7

5

2

2

2

1

1
Western Blotting (WB)

Specificité

The antibody detects endogenous level of PKM2 only

Immunogène

Peptide sequence around phosphorylation site of pSer37 (I-D-S (p) -P-P) derived from Human PKM2.

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anti-Pyruvate Kinase M2 (PKM2) (pTyr105) antibody
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anti-Pyruvate Kinase M2 (PKM2) (AA 383-417), (C-Term) antibody
PKM2 Reactivité: Humain WB, FACS, IHC (p) Hôte: Lapin Polyclonal RB18405 unconjugated

anti-Pyruvate Kinase M2 (PKM2) (AA 476-505) antibody
PKM2 Reactivité: Humain, Souris, Rat, Primate WB, IHC, ELISA, IF Hôte: Lapin Polyclonal unconjugated

anti-Pyruvate Kinase M2 (PKM2) (AA 116-145) antibody
PKM2 Reactivité: Humain WB, IHC, ELISA, FACS Hôte: Lapin Polyclonal unconjugated

anti-Pyruvate Kinase M2 (PKM2) (AA 255-350) antibody
PKM2 Reactivité: Humain, Souris, Rat WB, ELISA, FACS, IHC (p), IF (cc), IF (p), ICC, IHC (fro) Hôte: Lapin Polyclonal unconjugated

anti-Pyruvate Kinase M2 (PKM2) (AA 121-151), (N-Term) antibody
PKM2 Reactivité: Humain, Souris WB Hôte: Lapin Polyclonal RB5870 unconjugated

anti-Pyruvate Kinase M2 (PKM2) (AA 116-145), (N-Term) antibody
PKM2 Reactivité: Humain WB, FACS, IHC (p) Hôte: Lapin Polyclonal RB15338 unconjugated

Indications d'application

Western Blot: 1:500-1000

Restrictions

For Research Use only
Format

Liquid

Stock

4 °C/-20 °C
Yang, Zheng, Xia, Ji, Chen, Guo, Lyssiotis, Aldape, Cantley, Lu: "ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect." dans: Nature cell biology, Vol. 14, Issue 12, pp. 1295-304, (2012) (PubMed).
Antigène

PKM2 (Pyruvate Kinase M2 (PKM2))

Autre désignation

PKM2 (PKM2 Produits)

Synonymes

anticorps CTHBP, anticorps OIP3, anticorps PK3, anticorps PKM2, anticorps TCB, anticorps THBP1, anticorps AA414905, anticorps AL024370, anticorps AL024424, anticorps Pk-2, anticorps Pk-3, anticorps Pk3, anticorps Pkm2, anticorps PKM12, anticorps PKM, anticorps pyruvate kinase M1/2, anticorps pyruvate kinase, muscle, anticorps PKM, anticorps Pkm

Sujet

Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Poids moléculaire

60 kDa

Pathways

L'effet Warburg