CD130/gp130 anticorps

N° du produit ABIN1383685

Cet anticorps Souris Monoclonal détecte spécifiquement CD130/gp130 dans WB, IHC, ELISA, FACS, IP et Func. Il présente une réactivité envers Humain et a été mentionné dans 23+ publications.

Aperçu rapide pour CD130/gp130 anticorps (ABIN1383685)

Antigène: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD130/gp130 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)

Clone: B-S12

Détail du produit anti-CD130/gp130 anticorps

Specificité: Recognises the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein

Purification: Ion exchange chromatography

Stérilité: 0.22 μm filtered

Immunogène: Natural soluble gp130,Myeloma X63/AG.8653 x Balb/c spleen cells

Isotype: IgG1 kappa

Biological Activity Comment: Activates cells carrying gp130. Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

Agent conservateur: Without preservative

Stock: 4 °C

Stockage commentaire: Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

Références pour anticorps anti-CD130/gp130 (ABIN1383685)

Selander, Li, Watson, Merrell, Dahmen, Heinrich, Müller-Newen, Harris: "Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy." dans: Cancer research, Vol. 64, Issue 19, pp. 6924-33, (2004) (PubMed).

Ancey, Menet, Corbi, Fredj, Garcia, Rücker-Martin, Bescond, Morel, Wijdenes, Lecron, Potreau: "Human cardiomyocyte hypertrophy induced in vitro by gp130 stimulation." dans: Cardiovascular research, Vol. 59, Issue 1, pp. 78-85, (2003) (PubMed).

Giese, Au-Yeung, Herrmann, Diefenbach, Haan, Küster, Wortmann, Roderburg, Heinrich, Behrmann, Müller-Newen: "Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis." dans: The Journal of biological chemistry, Vol. 278, Issue 40, pp. 39205-13, (2003) (PubMed).

Wang, Gu, Huang, Zhu, Zhou, Xie, Xu, Qiu, Zhang: "gp130-linked signal transduction promotes the differentiation and maturation of dendritic cells." dans: International immunology, Vol. 14, Issue 6, pp. 599-603, (2002) (PubMed).

Jover, Bort, Gómez-Lechón, Castell: "Down-regulation of human CYP3A4 by the inflammatory signal interleukin-6: molecular mechanism and transcription factors involved." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 16, Issue 13, pp. 1799-801, (2002) (PubMed).

Voisin, Bitard, Daburon, Moreau, Taupin: "Separate functions for the two modules of the membrane-proximal cytokine binding domain of glycoprotein 190, the leukemia inhibitory factor low affinity receptor, in ligand binding and receptor activation." dans: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13682-92, (2002) (PubMed).

Ancey, Corbi, Froger, Delwail, Wijdenes, Gascan, Potreau, Lecron: "Secretion of IL-6, IL-11 and LIF by human cardiomyocytes in primary culture." dans: Cytokine, Vol. 18, Issue 4, pp. 199-205, (2002) (PubMed).

Kube, Holtick, Vockerodt, Ahmadi, Haier, Behrmann, Heinrich, Diehl, Tesch: "STAT3 is constitutively activated in Hodgkin cell lines." dans: Blood, Vol. 98, Issue 3, pp. 762-70, (2001) (PubMed).

Hammacher, Wijdenes, Hilton, Nicola, Simpson, Layton: "Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors." dans: The Biochemical journal, Vol. 345 Pt 1, pp. 25-32, (2000) (PubMed).

Kurth, Horsten, Pflanz, Timmermann, Küster, Dahmen, Tacken, Heinrich, Müller-Newen: "Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 1, pp. 273-82, (2000) (PubMed).

Olivier, Auguste, Chabbert, Lelièvre, Chevalier, Gascan: "Identification of a gp130 cytokine receptor critical site involved in oncostatin M response." dans: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5648-56, (2000) (PubMed).

Gu, De Vos, Rebouissou, Jourdan, Zhang, Rossi, Wijdenes, Klein: "Agonist anti-gp130 transducer monoclonal antibodies are human myeloma cell survival and growth factors." dans: Leukemia, Vol. 14, Issue 1, pp. 188-97, (2000) (PubMed).

Müller-Newen, Küster, Wijdenes, Schaper, Heinrich: "Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies." dans: The Journal of biological chemistry, Vol. 275, Issue 7, pp. 4579-86, (2000) (PubMed).

Kurth, Horsten, Pflanz, Dahmen, Küster, Grötzinger, Heinrich, Müller-Newen: "Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 3, pp. 1480-7, (1999) (PubMed).

Kallen, Grötzinger, Lelièvre, Vollmer, Aasland, Renné, Müllberg, Myer zum Büschenfelde, Gascan, Rose-John: "Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6." dans: The Journal of biological chemistry, Vol. 274, Issue 17, pp. 11859-67, (1999) (PubMed).

Thiel, Behrmann, Dittrich, Muys, Tavernier, Wijdenes, Heinrich, Graeve: "Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway." dans: The Biochemical journal, Vol. 330 ( Pt 1), pp. 47-54, (1998) (PubMed).

Hammacher, Richardson, Layton, Smith, Angus, Hilton, Nicola, Wijdenes, Simpson: "The immunoglobulin-like module of gp130 is required for signaling by interleukin-6, but not by leukemia inhibitory factor." dans: The Journal of biological chemistry, Vol. 273, Issue 35, pp. 22701-7, (1998) (PubMed).

Rebouissou, Wijdenes, Autissier, Tarte, Costes, Liautard, Rossi, Brochier, Klein: "A gp130 interleukin-6 transducer-dependent SCID model of human multiple myeloma." dans: Blood, Vol. 91, Issue 12, pp. 4727-37, (1998) (PubMed).

Simpson, Hammacher, Smith, Matthews, Ward: "Interleukin-6: structure-function relationships." dans: Protein science : a publication of the Protein Society, Vol. 6, Issue 5, pp. 929-55, (1997) (PubMed).

Lebeau, Montero Julian, Wijdenes, Müller-Newen, Dahmen, Chérel, Heinrich, Brailly, Hallet, Godard, Minvielle, Jacques: "Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties." dans: FEBS letters, Vol. 407, Issue 2, pp. 141-7, (1997) (PubMed).

Détails sur CD130/gp130

Antigène: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Autre désignation: CD130

Sujet: Gp130

Poids moléculaire: 130-140 kDa

Pathways: Signalistation JAK/STAT, Cellular Glucan Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Cancer Immune Checkpoints