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MCPH1 anticorps (AA 11-110)

MCPH1 Reactivité: Souris WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1385183
  • Antigène Voir toutes MCPH1 Anticorps
    MCPH1 (Microcephalin 1 (MCPH1))
    Épitope
    • 14
    • 11
    • 9
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 11-110
    Reactivité
    • 42
    • 22
    • 4
    • 1
    Souris
    Hôte
    • 49
    • 6
    • 1
    Lapin
    Clonalité
    • 51
    • 5
    Polyclonal
    Conjugué
    • 25
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MCPH1 est non-conjugé
    Application
    • 48
    • 24
    • 12
    • 12
    • 10
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
     Réactivité croisée
    Souris
    Homologie
    Human,Dog
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Microcephalin 1/BRIT1
    Isotype
    IgG
    Top Product
    Discover our top product MCPH1 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    MCPH1 (Microcephalin 1 (MCPH1))
    Autre désignation
    Microcephalin 1/BRIT1 (MCPH1 Produits)
    Synonymes
    anticorps RGD1560642, anticorps MGC83773, anticorps MCPH1, anticorps mct, anticorps brit1, anticorps MGC148665, anticorps BRIT1, anticorps MCT, anticorps 5430437K10Rik, anticorps D030046N04Rik, anticorps microcephalin 1, anticorps microcephalin 1 S homeolog, anticorps microcephaly, primary autosomal recessive 1, anticorps Mcph1, anticorps mcph1.S, anticorps MCPH1, anticorps mcph1
    Sujet

    Synonyms: BRCT repeat inhibitor of TERT expression 1, BRIT 1, FLJ12847, Hypothetical protein FLJ12847, MCPH 1, MCPH1, MCPH1_HUMAN, MCT antibody Microcephalin 1, Microcephalin-1, Microcephaly primary autosomal recessive 1.

    Background: Microcephalin modulates brain size and has been proliferating under strong positive selection for several thousand years, although the nature of the positive selection is poorly understood. Human Microcephalin contains three BRCA1 C-terminal (BRCT) domains and shares 57 % identity with its mouse ortholog, the most conserved regions being BRCT domains where there is 80 % identity. Predominant expression of human Microcephalin is observed in fetal brain, liver and kidney tissues and is expressed during neurogenesis in mice. Microcephalin displays significantly higher rates of protein evolution in primates than in rodents, this trend is most noticeable for the subset of genes associated with nervous system development. Microcephalin has a very young, single nucleotide, polymorphism haplotype associated with modern humans, this gene is presumably still evolving in Homo sapiens. It functions in DNA damage response and regulation of cell cycle checkpoints.

    Pathways
    Stem Cell Maintenance
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