DMO/Dmrt1a (AA 51-100) anticorps

N° du produit ABIN1386037

Cet anticorps Lapin Polyclonal détecte spécifiquement not_set dans WB, IF (cc), IF (p), ELISA, IHC (fro), IHC (p) et ICC. Il présente une réactivité envers Humain, Souris, Rat et Mouton et a été mentionné dans 1 publication.

Aperçu rapide pour DMO/Dmrt1a (AA 51-100) anticorps (ABIN1386037)

Antigène: DMO/Dmrt1a

Reactivité: Humain, Souris, Rat, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Détail du produit

Épitope: AA 51-100

Réactivité croisée: Humain, Souris, Rat, Mouton

Homologie: Dog,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Dmrt1a

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Référence

Li, Lu, Luo, Gao, Zhao, Ma: "Expression and cellular localization of double sex and mab-3 related transcription factor 1 in testes of postnatal Small-Tail Han sheep at different developmental stages." dans: Gene, Vol. 642, pp. 467-473, (2017) (PubMed).

Détail du antigène

Antigène: DMO/Dmrt1a

Sujet:

Synonyms: DMT1, CT154, Doublesex- and mab-3-related transcription factor 1, DM domain expressed in testis protein 1, DMRT1

Background: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).

ID gène: 1761

UniProt: Q9Y5R6