DMO/Dmrt1a (AA 51-100) anticorps

N° du produit ABIN1386037

Cet anticorps Lapin Polyclonal détecte spécifiquement dans WB, IF (cc), IF (p), ELISA, IHC (fro), IHC (p) et ICC. Il présente une réactivité envers Humain, Souris, Rat et Mouton et a été mentionné dans 1 publication.

Aperçu rapide pour DMO/Dmrt1a (AA 51-100) anticorps (ABIN1386037)

Antigène: DMO/Dmrt1a

Reactivité: Humain, Souris, Rat, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Détail du produit

Épitope: AA 51-100

Réactivité croisée: Humain, Souris, Rat, Mouton

Homologie: Dog,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Dmrt1a

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Référence

Li, Lu, Luo, Gao, Zhao, Ma: "Expression and cellular localization of double sex and mab-3 related transcription factor 1 in testes of postnatal Small-Tail Han sheep at different developmental stages." dans: Gene, Vol. 642, pp. 467-473, (2017) (PubMed).

Détail du antigène

Antigène: DMO/Dmrt1a

Sujet:

Synonyms: DMT1, CT154, Doublesex- and mab-3-related transcription factor 1, DM domain expressed in testis protein 1, DMRT1

Background: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).

ID gène: 1761

UniProt: Q9Y5R6