NGEF anticorps (AA 451-550)

N° du produit ABIN1386121

Cet anticorps Lapin Polyclonal détecte spécifiquement NGEF dans WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) et ICC. Il présente une réactivité envers Souris et Rat.

Aperçu rapide pour NGEF anticorps (AA 451-550) (ABIN1386121)

Antigène: NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NGEF est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Détail du produit anti-NGEF anticorps

Épitope: AA 451-550

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human EPHEXIN

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur NGEF

Antigène: NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))

Autre désignation: Ephexin-1/EPHEXIN

Sujet:

Synonyms: EPHEXIN, ARHGEF27, Ephexin-1, Eph-interacting exchange protein, Neuronal guanine nucleotide exchange factor, NGEF

Background: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).

ID gène: 25791

UniProt: Q8N5V2

Pathways: Neurotrophin Signaling Pathway