AFG3L2 anticorps (AA 531-600)

N° du produit ABIN1386200

L’anticorps Lapin Polyclonal anti-AFG3L2 a été validé pour ELISA, IHC (p), ICC, IF (cc), IF (p) et IHC (fro). Il convient pour détecter AFG3L2 dans des échantillons de Souris et Rat.

Aperçu rapide pour AFG3L2 anticorps (AA 531-600) (ABIN1386200)

Antigène: AFG3L2 (AFG3-Like Protein 2 (AFG3L2))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AFG3L2 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-AFG3L2 anticorps

Épitope: AA 531-600

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human AFG3L2

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur AFG3L2

Antigène: AFG3L2 (AFG3-Like Protein 2 (AFG3L2))

Autre désignation: SCA28/AFG3L2

Sujet:

Synonyms: AFG3 ATPase family gene 3, yeast like 2, AFG3 ATPase family gene 3 like 2 yeast, AFG3 ATPase family gene 3 like 2, AFG3 like protein 2, ATPase family gene 3 like 2, ATPase family gene 3 yeast, FLJ25993, Paraplegin like protein, SCA28, Spinocerebellar ataxia 28, AFG32_HUMAN .

Background: AFG3L2 is a multi-pass membrane metalloprotease that contains one AAA (ATPase associated with diverse cellular activities) domain, a zinc-dependent binding motif, an RNA-binding region and an ATP/GTP binding site. Localizing to the mitochondrial membrane, AFG3L2 is ubiquitously expressed with highest expression levels in skeletal muscle and heart. AFG3L2 shares 69 % similarity with the yeast Afg3 protein and 49 % similarity with Paraplegin, a protein of mitochondria that is thought to be involved in signal transduction and chaperone-like activities. In mitochondria, AFG3L2 forms a complex with Paraplegin that is believed to regulate essential protein quality control. Mutations in the gene encoding either one of these proteins can result in hereditary spastic paraplegia, a degenerative spinal cord disorder that is characterized by muscle spasms, stiffness in the legs and, in some cases, incontinence.

Pathways: Skeletal Muscle Fiber Development