KALRN anticorps (AA 1401-1500)

N° du produit ABIN1386312

Cet anticorps anti-KALRN est un anticorps Lapin Polyclonal détectant KALRN dans ELISA, IF (cc), IF (p), ICC, IHC (fro) et IHC (p). Adapté pour Humain.

Aperçu rapide pour KALRN anticorps (AA 1401-1500) (ABIN1386312)

Antigène: KALRN (Kalirin, RhoGEF Kinase (KALRN))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KALRN est non-conjugé

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-KALRN anticorps

Épitope: AA 1401-1500

Homologie: Human,Mouse,Rat,Dog,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human KALRN/Duo

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur KALRN

Antigène: KALRN (Kalirin, RhoGEF Kinase (KALRN))

Autre désignation: KALRN/Duo

Sujet:

Synonyms: Duo, FLJ16443, HAPIP, Huntingtin associated protein interacting protein duo , Huntingtin-associated protein-interacting protein, Kalirin isoform 2, Kalirin, KALRN , KALRN_HUMAN , Protein Duo, RhoGEF kinase, Serine/threonine kinase with Dbl and pleckstrin homology domains , Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, TRAD.

Background: HAP1 (huntingtin-associated protein 1) binds to huntingtin (1). Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington?s disease (HD) (2,3). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region (1). HAP1 shows neuronal localization and moves with huntingtin in nerve fibers (4,5). HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem (1). Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons (6). Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.

Pathways: Neurotrophin Signaling Pathway