KDM4B anticorps (pThr305)

N° du produit ABIN1386741

Cet anticorps anti-KDM4B est un anticorps Lapin Polyclonal détectant KDM4B dans WB, ELISA, ICC, IHC (p), IF (cc), IF (p) et IHC (fro). Adapté pour Souris et Rat.

Aperçu rapide pour KDM4B anticorps (pThr305) (ABIN1386741)

Antigène: KDM4B (Lysine (K)-Specific Demethylase 4B (KDM4B))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KDM4B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-KDM4B anticorps

Épitope: pThr305

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Sheep

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human JMJD2B around the phosphorylation site of Thr305

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur KDM4B

Antigène: KDM4B (Lysine (K)-Specific Demethylase 4B (KDM4B))

Autre désignation: JMJD2B

Sujet:

Synonyms: KDM4B/JMJD2B phospho T305, KDM4B/JMJD2B phospho Thr305, p-KDM4BT305, p-KDM4BThr305, JHDM3B, JmjC domain-containing histone demethylation protein 3B, JMJD2B, JmjC domain-containing histone demethylation protein 3A, Jumonji domain containing protein 2B, KIAA0876, Lysine-specic demethylase 4B, KDM4B_HUMAN.

Background: JMJD2B is a 1,064 amino acid protein encoded by the human gene JMJD2B. JMJD2B belongs to the JMJD2B histone demethylase family and contains one JmjC domain, one JmjN domain, two PHD-type zinc fingers and two Tudor domains. The two Tudor domains recognize and bind methylated histones and have an interdigitated structure, the unusual fold is required for its ability to bind methylated histone tails. JMJD2B is a histone demethylase that specifically demethylates Lys 9 residues of Histone H3, thereby playing a role in histone code. It does not demethylate Histone H3 Lys 4, H3 Lys 27, H3 Lys 36 or H4 Lys 20, however, and is only able to demethylate trimethylated H3 Lys-9 and has weaker activity than JMJD2A, JMJD2C and JMJD2D. JMJD2B demethyl-ation of Lysine residues will generate formaldehyde and succinate. JMJD2B is a ubiquitously expressed nuclear protein.

ID gène: 23030

Pathways: L'effet Warburg