SOX10 anticorps

N° du produit ABIN1386776

Détail du produit anti-SOX10 anticorps

Antigène: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOX10 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SOX10

Isotype: IgG

Information d'application

Indications d'application: WB: 1:100-1000, IHC-P: 1:100-500, IF(IHC-P): 1:50-200
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur SOX10

Antigène: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Autre désignation: Sox10 (SOX10 Produits)

Synonymes: anticorps DOM, anticorps PCWH, anticorps WS2E, anticorps WS4, anticorps WS4C, anticorps SOX-10, anticorps SOX10, anticorps dom, anticorps ws4, anticorps Dom, anticorps Sox21, anticorps SOX9, anticorps cls/sox10, anticorps zgc:100757, anticorps SRY-box 10, anticorps SRY box 10, anticorps SRY-box 10 L homeolog, anticorps SRY (sex determining region Y)-box 10, anticorps SOX10, anticorps Sox10, anticorps sox10.L, anticorps sox10

Sujet:

Synonyms: DOM, MGC15649, SOX 10, SOX10, SOX10_HUMAN, SRY sex determining region Y box 10, SRY box containing gene 10, SRY related HMG box gene 10, Transcription factor SOX 10, Transcription factor SOX-10, WS4.

Background: Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia. Involvement in disease, Defects in SOX10 are the cause of Waardenburg syndrome type 2E (WS2E) . WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1.Defects in SOX10 are a cause of Waardenburg syndrome type 4C (WS4C), also known as Waardenburg-Shah syndrome. WS4C is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease).Defects in SOX10 are a cause of Yemenite deaf-blind hypopigmentation syndrome (YDBHS) . YDBHS consists of cutaneous hypopigmented and hyperpigmented spots and patches, microcornea, coloboma and severe hearing loss. Another case observed in a girl with similar skin symptoms and hearing loss but without microcornea or coloboma is reported as a mild form of this syndrome.

ID gène: 6663

Pathways: Chromatin Binding