FKBP5 anticorps (AA 201-300)

N° du produit ABIN1387240

Cet anticorps Lapin Polyclonal détecte spécifiquement FKBP5 dans ELISA et IHC (p). Il présente une réactivité envers Souris et Rat.

Aperçu rapide pour FKBP5 anticorps (AA 201-300) (ABIN1387240)

Antigène: FKBP5 (FK506 Binding Protein 5 (FKBP5))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FKBP5 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-FKBP5 anticorps

Épitope: AA 201-300

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Sheep,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human FKBP51

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur FKBP5

Antigène: FKBP5 (FK506 Binding Protein 5 (FKBP5))

Autre désignation: FKBP51

Sujet:

Synonyms: FKBP 5, FKBP 51, FKBP 54, FKBP-5, FKBP-51, FKBP5, FKBP5_HUMAN, FKBP54, HSP90 binding immunophilin, HSP90-binding immunophilin, P54 antibody Peptidyl prolyl cis trans isomerase, Peptidyl-prolyl cis-trans isomerase FKBP5, Peptidylprolyl cis trans isomerase, PPIase, PPIase FKBP5, Ptg 10, Ptg10, Rotamase, T cell FK506 binding protein, 51 kDa FK506 binding protein 5, 51 kDa FK506 binding protein, 51 kDa FK506-binding protein, 51 kDa FKBP, 54 kDa progesterone receptor associated immunophilin, 54 kDa progesterone receptor-associated immunophilin, AIG 6, AIG6, Androgen regulated protein 6, Androgen-regulated protein 6, FF1 antigen, FK506 binding protein 5, FK506-binding protein 5, MGC111006, OTTHUMP00000016268.

Background: The immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases that bind to and mediate the effects of immunosuppressive drugs, such as cyclosporin, FK506 and rapamycin (1). Several related immunophilins, FKBP12, FKBP51 and FKBP52, are characterized as cytosolic FK506-binding proteins, and following ligand binding, they functionally inhibit the phosphatase activity of calcineurin (2,3). The ubiquitously expressed FKBP12 also associates with the cytoplasmic domain of the TGF?type I receptor, where it stabilizes the inactive conformation of the receptor and blocks the activation of the TGF?pathway (4). FKBP51 and FKBP52 are two highly related proteins (5,6). FKBP51 is predominantly expressed in T cells and is induced by glucocorticoids (5). FKBP51 mediates the effects of FK506 and rapamycin by inhibiting intracellular calcineurin activity, and by blocking T-cell activation and proliferation (7). FKBP52, known also as FKBP-59 or heat shock protein 56, is expressed in a variety of tissues and can also associate with the heat shock protein (hsp90) in mature steroid receptor complexes (6,8).