Ensa anticorps (AA 51-121)

N° du produit ABIN1387412

L’anticorps Lapin Polyclonal anti-Ensa a été validé pour ELISA, WB, IF (cc), IF (p), ICC, IHC (p) et IHC (fro). Il convient pour détecter Ensa dans des échantillons de Humain.

Aperçu rapide pour Ensa anticorps (AA 51-121) (ABIN1387412)

Antigène: Ensa (ENSA) (Endosulfine alpha (ENSA))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ensa est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-Ensa anticorps

Épitope: AA 51-121

Homologie: Human,Mouse,Rat,Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ENSA/ARPP-19

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Ensa

Antigène: Ensa (ENSA) (Endosulfine alpha (ENSA))

Autre désignation: ENSA/ARPP-19

Sujet:

Synonyms: Alpha endosulfine, ARPP 19e, Endosulfine alpha, ENSA_HUMAN.

Background: Sulfonylureas are a class of drugs commonly used in the management of noninsulin-dependent diabetes mellitus. ENSA/ARPP-19, also known as ARPP-19e, is a 121 amino acid protein that localizes to the cytoplasm and belongs to the endosulfine family. ENSA/ARPP-19 is an endogenous regulator of the _-cell K(ATP) channels and reduces K(ATP) channel currents by inhibiting sulfonylurea from binding to the receptor thereby stimulating insulin secretion by pancreatic _ cells. It is suggested that ENSA/ARPP-19 expression is decreased in brains of both Alzheimer's disease (AD) and Down's syndrome patients. Widely expressed with high levels in skeletal muscle and brain and lower levels in pancreas, ENSA/ARPP-19 is phosphorylated by PKA and exists as eight alternatively spliced isoforms. ENSA/ARPP-19 is encoded by a gene located on human chromosome 1q21.3.