SUFUH anticorps (AA 433-484) (Biotin)

N° du produit ABIN1389919

Cet anticorps Lapin Polyclonal détecte spécifiquement SUFUH dans WB, ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour SUFUH anticorps (AA 433-484) (Biotin) (ABIN1389919)

Antigène: SUFUH (Suppressor of Fused Homolog (SUFUH))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SUFUH est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-SUFUH anticorps (Biotin)

Épitope: AA 433-484

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SUFU

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur SUFUH

Antigène: SUFUH (Suppressor of Fused Homolog (SUFUH))

Autre désignation: SUFU/Suppressor of Fused

Sujet:

Synonyms: SUFUH, SUFUXL, PRO1280, Suppressor of fused homolog, SUFU, UNQ650/PRO1280

Background: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity).

ID gène: 51684

UniProt: Q9UMX1

Pathways: Signalisation Hedgehog, Tube Formation, Maintenance of Protein Location