HAS2 anticorps (AbBy Fluor® 488)

N° du produit ABIN1390390

Cet anticorps Lapin Polyclonal détecte spécifiquement HAS2 dans WB et IF (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour HAS2 anticorps (AbBy Fluor® 488) (ABIN1390390)

Antigène: HAS2 (Hyaluronan Synthase 2 (HAS2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HAS2 est conjugé à/à la AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-HAS2 anticorps (AbBy Fluor® 488)

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HAS2/Hyaluronan synthase 2

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P): (1:50-200)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur HAS2

Antigène: HAS2 (Hyaluronan Synthase 2 (HAS2))

Autre désignation: Has2

Sujet:

Synonyms: HA synthase 2, has2, HAS2_HUMAN, Hyaluronan synthase 2, Hyaluronate synthase 2, Hyaluronic acid synthase 2.

Background: HAS1, HAS2 and HAS3 are HA Synthase proteins that synthesize HA (Hyaluronan or hyaluronic acid). The extracellular matrix in most vertebrates express HA, which is a high molecular weight linear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues linked by i²-1,3 and i²-1,4 glycosidic bonds. The three HAS genes show distinct patterns of expression during development and their protein products play significantly different roles in the formation of the HA matrix. Both HAS1 and HAS2 synthesise high molecular-weight HA, whereas HAS3 produces lower molecular weight HA. The expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially regulated by various stimuli suggesting distinct functional roles of the three proteins. HAS2 mRNA shows predominant expression in chondrocytes and cartilage. The human HAS2 gene maps to chromosome 8q24.12.

Pathways: Glycosaminoglycan Metabolic Process