APBB2 anticorps (AA 251-350) (Biotin)

N° du produit ABIN1392397

Cet anticorps Lapin Polyclonal détecte spécifiquement APBB2 dans WB, ELISA, IHC (p) et IHC (fro). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour APBB2 anticorps (AA 251-350) (Biotin) (ABIN1392397)

Antigène: APBB2 (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 (APBB2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APBB2 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-APBB2 anticorps (Biotin)

Épitope: AA 251-350

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human APBB2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur APBB2

Antigène: APBB2 (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 (APBB2))

Autre désignation: APBB2/FE65L1

Sujet:

Synonyms: Amyloid beta A4 precursor protein-binding, family B, member 2 Fe65 like, Amyloid beta A4 precursor protein binding family B member 2, Amyloid beta A4 precursor protein-binding family B member 2, APBB 2, APBB2, APBB2_HUMAN, Fe65 like 1, Fe65 like, Fe65 like protein, FE65L 1, FE65L, FE65L1, Protein Fe65-like 1, Rirl 1, Rirl1, TR2 L, TR2L, Zfra, Zinc finger like protein.

Background: Fe65L is a 758 amino acid protein that contains one WW domain and two PID domains. Binding to the intracellular domain of the -Amyloid precursor protein, Fe65L is thought to modulate the internalization and, therefore, the accessibility and function of -Amyloid. Via its ability to control the intracellular accumulation of -Amyloid, Fe65L is thought to play a role in the pathogenesis of Alzheimer's disease. Multiple isoforms of Fe65L exist due to alternative splicing events. The gene encoding Fe65L maps to human chromosome 4, which encodes nearly 6 % of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.