CADPS anticorps (AA 151-250) (Biotin)

N° du produit ABIN1393471

Cet anticorps Lapin Polyclonal détecte spécifiquement CADPS dans IHC (fro). Il présente une réactivité envers Humain.

Aperçu rapide pour CADPS anticorps (AA 151-250) (Biotin) (ABIN1393471)

Antigène: CADPS (Ca++-Dependent Secretion Activator (CADPS))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CADPS est conjugé à/à la Biotin

Application: Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-CADPS anticorps (Biotin)

Épitope: AA 151-250

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CAPS1

Isotype: IgG

Information d'application

Indications d'application: IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur CADPS

Antigène: CADPS (Ca++-Dependent Secretion Activator (CADPS))

Autre désignation: CAPS1

Sujet:

Synonyms: Cadps, CADPS1, Calcium dependent secretion activator 1, Calcium-dependent activator protein for secretion 1, Calcium-dependent secretion activator 1, Caps, CAPS-1, rCAPS, CAPS1_HUMAN.

Background: Calcium-dependent secretion activators (CAPS-1 and CAPS-2) are calcium-binding proteins that direct neurotransmitter and neuropeptide-filled vesicles to the cell membrane for secretory granule exocytosis. Both CAPS-1 and CAPS-2 are expressed primarily in the brain where they regulate the secretion of various substances. The CAPS proteins contain a PH domain that is essential for regulation of exocytosis, as well as regulation of phospholipid binding. Through their regulation of neurotrophin release from granule cells, CAPS proteins help to regulate cell fate during neuronal development. CAPS-1 is thought to regulate catecholamine release from neuronal cells, while CAPS-2 is thought to regulate release of both brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) from granule cells. Defects in the genes encoding CAPS-1 and CAPS-2 are implicated in impaired cerebral development and autism.

Pathways: Synaptic Vesicle Exocytosis