UBE2C anticorps (AA 101-179) (Biotin)

N° du produit ABIN1398613

Cet anticorps Lapin Polyclonal détecte spécifiquement UBE2C dans WB, ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Humain.

Aperçu rapide pour UBE2C anticorps (AA 101-179) (Biotin) (ABIN1398613)

Antigène: UBE2C (Ubiquitin-Conjugating Enzyme E2C (UBE2C))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBE2C est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-UBE2C anticorps (Biotin)

Épitope: AA 101-179

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human UBE2C

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur UBE2C

Antigène: UBE2C (Ubiquitin-Conjugating Enzyme E2C (UBE2C))

Autre désignation: UBE2C

Sujet:

Synonyms: Cyclin selective ubiquitin carrier protein, dJ447F3.2, Mitotic specic ubiquitin conjugating enzyme, UB E2C, UBCH 10, UBCH10, UBE 2C, Ube2c, UBE2C_HUMAN, Ubiquitin carrier protein C, Ubiquitin carrier protein E2 C, Ubiquitin carrier protein E2C, Ubiquitin conjugating enzyme E2 C, Ubiquitin conjugating enzyme E2C, Ubiquitin protein ligase C, Ubiquitin-conjugating enzyme E2 C, Ubiquitin-protein ligase C.

Background: The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ub-conjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2C, also designated UBCH10 in human, is an E2 ubiquitin conjugating enzyme for the anaphase promoting complex (APC), which coordinates mitosis and G1 by sequentially promoting the degradation of key cell-cycle regulators. UBE2C is overexpressed in many different types of cancers and may be a potential therapeutic target.

ID gène: 11065

Pathways: Ubiquitin Proteasome Pathway