Transglutaminase 2 anticorps (AA 351-450) (FITC)

N° du produit ABIN1399904

L’anticorps anti-Transglutaminase 2 Polyclonal Lapin est utilisé pour la détection de Transglutaminase 2 dans des échantillons de Humain et Souris. Il a été validé pour WB, IF (cc) et IF (p).

Aperçu rapide pour Transglutaminase 2 anticorps (AA 351-450) (FITC) (ABIN1399904)

Antigène: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Transglutaminase 2 est conjugé à/à la FITC

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-Transglutaminase 2 anticorps (FITC)

Épitope: AA 351-450

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Transglutaminase 2

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Transglutaminase 2

Antigène: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Autre désignation: Transglutaminase 2

Sujet:

Synonyms: TG 2, TGC, TG2, TGase C, TGase H, TGase-2, TGase2, TgaseII, ALPHA SUBUNIT, C polypeptide, G alpha h, G protein alpha subunit Gh class, G[a]h, Gh CLASS G ALPHA h, GNAH, GNAH G PROTEIN, Guanine nucleotide binding protein H polypeptide, H POLYPEPTIDE, Protein glutamine gamma glutamyltransferase 2, Protein glutamine gamma glutamyltransferase, Protein-glutamine gamma-glutamyltransferase 2, TGC, TGC GUANINE NUCLEOTIDE BINDING PROTEIN, TGM 2, TGM2, TGM2_HUMAN, Tissue transglutaminase, Tissue type transglutaminase, Transglutaminase 2, Transglutaminase 2 C polypeptide, Transglutaminase C, Transglutaminase H, Transglutaminase-2, tTG, tTGas.

Background: Terminally differentiating mammalian epidermal cells acquire an insoluble, 10 to 20 nm thick protein deposit on the intracellular surface of the plasma membrane known as the cross-linked cell envelope (CE). The CE is a component of the epidermis that is generated through formation of disulfide bonds and g-glutamyl-lysine isodipeptide bonds, which are formed by the action of transglutaminases (TGases). TGases are intercellularly localizing, Ca2+-dependent enzymes that catalyze the formation of isopeptide bonds by transferring an amine on to glutaminyl residues, thereby cross-linking glutamine residues and lysine residues in substrate proteins. TGases influence numerous biological processes, including blood coagulation, epidermal differentiation, seminal fluid coagulation, fertilization, cell differentiation and apoptosis. Human keratinocyte transglutaminase (TGase1) is a membrane associated, 817 amino acid protein. Human tissue transglutaminase (TGase2) is an endothelial cell specific, 687 amino acid protein.

Pathways: Tube Formation, Thromboxane A2 Receptor Signaling