NCF1 anticorps (pSer359) (HRP)

N° du produit ABIN1409210

L’anticorps Lapin Polyclonal anti-NCF1 a été validé pour WB, ELISA et IHC (fro). Il convient pour détecter NCF1 dans des échantillons de Rat.

Aperçu rapide pour NCF1 anticorps (pSer359) (HRP) (ABIN1409210)

Antigène: NCF1 (Neutrophil Cytosol Factor 1 (NCF1))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NCF1 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-NCF1 anticorps (HRP)

Épitope: pSer359

Réactivité croisée: Rat

Homologie: Human

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human NCF1 around the phosphorylation site of Ser359

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur NCF1

Antigène: NCF1 (Neutrophil Cytosol Factor 1 (NCF1))

Autre désignation: NCF1/p47 phox

Sujet:

Synonyms: NCF1Ser359, p47 phoxSer359, NCF1 phospho S359, 47 kDa autosomal chronic granulomatous disease protein, 47 kDa neutrophil oxidase factor, NADPH oxidase organizer 2, NCF 47K, Neutrophil cytosol factor 1, Neutrophil cytosolic factor 1, Neutrophil NADPH oxidase factor 1, Nox organizer 2, Nox organizing protein 2, NOXO2, p47 phox, p47phox, ,SH3 and PX domain containing protein 1A, SH3PXD1A, NADPH oxidase p47 phox, NCF1_HUMAN.

Background: The heredity chronic granulomatous disease (CGF) has been linked to mutations in p47-phox and p67-phox. The cytosolic proteins p47-phox and p67-phox, also designated neutrophil cytosol factor (NCF)1 and NCF2, respectively, are required for activation of the superoxide-producing NADPH oxidase in neutrophils and other phagocytic cells. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex. Both p47-phox and p67-phox contain two Src homology 3 (SH3) domains. The C-terminal SH3 domain of p67-phox has been shown to interact with the proline-rich domain of p47-phox, suggesting that p47-phox may faciliate the transport of p67-phox to the membrane.

ID gène: 653361

Pathways: Signalisation PI3K-Akt