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UNC5D anticorps (AA 112-200) (Cy5)

UNC5D Reactivité: Humain WB, IF (cc), IF (p) Hôte: Lapin Polyclonal Cy5
N° du produit ABIN1409488
  • Antigène Voir toutes UNC5D Anticorps
    UNC5D (Unc-5 Homolog D (UNC5D))
    Épitope
    • 14
    • 7
    • 7
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    AA 112-200
    Reactivité
    • 36
    • 1
    Humain
    Hôte
    • 33
    • 3
    Lapin
    Clonalité
    • 34
    • 2
    Polyclonal
    Conjugué
    • 10
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp UNC5D est conjugé à/à la Cy5
    Application
    • 32
    • 22
    • 12
    • 12
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human UNC5H4
    Isotype
    IgG
    Top Product
    Discover our top product UNC5D Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    UNC5D (Unc-5 Homolog D (UNC5D))
    Autre désignation
    UNC5D/UNC5H4 (UNC5D Produits)
    Synonymes
    anticorps UNC5D, anticorps PRO34692, anticorps Unc5h4, anticorps D930029E11Rik, anticorps mKIAA1777, anticorps unc-5 netrin receptor D, anticorps unc-5 homolog D (C. elegans), anticorps Unc5d, anticorps UNC5D, anticorps unc5d
    Sujet

    Synonyms: Netrin receptor UNC5D, Netrin receptor Unc5h4, Protein unc 5 homolog D, Unc 5 homolog 4, Unc 5 homolog D C. elegans, Unc 5 homolog D, UNC 5D, Unc5h4, FLJ16019, KIAA1777.

    Background: The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is down-regulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. UNC5H4, also known as UNC5D (unc-5 homolog D), is single-pass type I membrane protein that is a member of the UNC5H netrin receptor family. Two isoforms of UNC5H4 exist due to alternative splicing events.

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