DISP2 anticorps (AA 1101-1200) (Cy5)

N° du produit ABIN1410052

Cet anticorps Lapin Polyclonal détecte spécifiquement DISP2 dans IF (cc) et IF (p). Il présente une réactivité envers Humain.

Aperçu rapide pour DISP2 anticorps (AA 1101-1200) (Cy5) (ABIN1410052)

Antigène: DISP2 (Dispatched Homolog 2 (DISP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DISP2 est conjugé à/à la Cy5

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-DISP2 anticorps (Cy5)

Épitope: AA 1101-1200

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human DISP2

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur DISP2

Antigène: DISP2 (Dispatched Homolog 2 (DISP2))

Autre désignation: DISP2

Sujet:

Synonyms: DISPB, HsT16908, Protein dispatched homolog 2, DISP2, KIAA1742

Background: DISP2 is the second of three known homologs of the D.melanogaster protein Dispatched. It is a multitransmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants. At least two isoforms of DISP2 are known to exist.

ID gène: 85455

UniProt: A7MBM2

Pathways: Signalisation Hedgehog