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DISP2 anticorps (AA 1101-1200) (Cy5)

DISP2 Reactivité: Humain IF (cc), IF (p) Hôte: Lapin Polyclonal Cy5
N° du produit ABIN1410052
  • Antigène Voir toutes DISP2 Anticorps
    DISP2 (Dispatched Homolog 2 (DISP2))
    Épitope
    • 14
    • 2
    • 2
    • 1
    • 1
    AA 1101-1200
    Reactivité
    • 18
    • 2
    • 2
    Humain
    Hôte
    • 18
    Lapin
    Clonalité
    • 18
    Polyclonal
    Conjugué
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp DISP2 est conjugé à/à la Cy5
    Application
    • 12
    • 12
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human DISP2
    Isotype
    IgG
    Top Product
    Discover our top product DISP2 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    DISP2 (Dispatched Homolog 2 (DISP2))
    Autre désignation
    DISP2 (DISP2 Produits)
    Synonymes
    anticorps DISP2, anticorps DISPB, anticorps HsT16908, anticorps AI840597, anticorps B230210L08Rik, anticorps DispB, anticorps mKIAA1742, anticorps dispatched RND transporter family member 2, anticorps dispatched RND tramsporter family member 2, anticorps dispatched homolog 2 (Drosophila), anticorps DISP2, anticorps Disp2
    Sujet

    Synonyms: DISPB, HsT16908, Protein dispatched homolog 2, DISP2, KIAA1742

    Background: DISP2 is the second of three known homologs of the D.melanogaster protein Dispatched. It is a multitransmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants. At least two isoforms of DISP2 are known to exist.

    ID gène
    85455
    UniProt
    A7MBM2
    Pathways
    Signalisation Hedgehog
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