ALIX anticorps (AA 301-380) (HRP)

N° du produit ABIN1410746

Détail du produit anti-ALIX anticorps (HRP)

Antigène: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Épitope: AA 301-380

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALIX est conjugé à/à la HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human AIP1

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur ALIX

Antigène: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Autre désignation: AIP1 (PDCD6IP Produits)

Synonymes: anticorps DDBDRAFT_0167145, anticorps DDBDRAFT_0185177, anticorps DDB_0167145, anticorps DDB_0185177, anticorps AIP1, anticorps ALIX, anticorps DRIP4, anticorps HP95, anticorps AI480591, anticorps AW544830, anticorps Aip1, anticorps Alix, anticorps C76364, anticorps Eig2, anticorps mKIAA1375, anticorps CG12876, anticorps DAIP1, anticorps Dmel\\CG12876, anticorps GB11744, anticorps RGD1561176, anticorps zgc:63638, anticorps wu:fb70d03, anticorps wu:fy65h02, anticorps PDCD6IP, anticorps aip1, anticorps alix, anticorps hp95, anticorps drip4, anticorps ALG-2 interacting protein X, anticorps programmed cell death 6 interacting protein, anticorps programmed cell death 6-interacting protein, anticorps Programmed cell death 6 interacting protein, anticorps programmed cell death 6 interacting protein L homeolog, anticorps alxA, anticorps PDCD6IP, anticorps Pdcd6ip, anticorps ALiX, anticorps LOC412662, anticorps pdcd6ip, anticorps Bm1_48390, anticorps pdcd6ip.L

Sujet:

Synonyms: Activin receptor interacting protein 1, Acvri1, Acvrinp1, ACVRIP1, AIP 1, Aip-1, ARIP1, Atrophin 1 interacting protein 1, Atrophin 1 interacting protein A, Atrophin-1-interacting protein 1, Atrophin-1-interacting protein A, MAGI-2, MAGI2, MAGI2_HUMAN, Membrane associated guanylate kinase 2, Membrane associated guanylate kinase inverted 2, Membrane associated guanylate kinase WW and PDZ domain containing 2, Membrane associated guanylate kinase WW and PDZ domain containing protein 2, Membrane-associated guanylate kinase, Membrane-associated guanylate kinase inverted 2, S SCAM, SSCAM, WW and PDZ domain-containing protein 2.

Background: AIP1 (ASK-interacting protein 1), also known as DAB2IP (DAB2 interacting protein), is a 1,189 amino acid protein that localizes to both the membrane and the cytoplasm and contains one Ras-GAP domain, one PH domain and one C2 domain. Expressed at low levels in prostate tissue, AIP1 functions as a Ras GTPase-activating protein that interacts with ASK 1 and, via this interaction, disrupts the association of ASK 1 with an inhibitory 14-3-3 complex, thereby allowing free ASK 1 to function within the cell. AIP1 exists as multiple alternatively spliced isoforms and is down-regulated in prostate cancer tissue, suggesting a role in tumor suppression. Chromosomal aberrations in the gene encoding AIP1 are associated with acute myeloid leukemia (AML), implicating a role for AIP1 fusion proteins in tumorigenesis.

Pathways: Signalisation p53, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation