EN1 anticorps (AA 351-392) (HRP)

N° du produit ABIN1410962

L’anticorps Lapin Polyclonal anti-EN1 a été validé pour WB, ELISA, IHC (p) et IHC (fro). Il convient pour détecter EN1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour EN1 anticorps (AA 351-392) (HRP) (ABIN1410962)

Antigène: EN1 (Engrailed Homeobox 1 (EN1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EN1 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-EN1 anticorps (HRP)

Épitope: AA 351-392

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human EN1/Engrailed 1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur EN1

Antigène: EN1 (Engrailed Homeobox 1 (EN1))

Autre désignation: EN1/Engrailed 1

Sujet:

Synonyms: En 1, EN1, Engrailed 1, Engrailed, Engrailed homeobox 1, Engrailed homolog 1, HME1_HUMAN, Homeobox protein en-1, Homeobox protein engrailed 1, Homeobox protein engrailed-1, Hu-En-1, Mo-en.1.

Background: The engrailed-1 gene, EN1, a murine homolog of the Drosophila homeobox gene engrailed (EN), is required for midbrain and cerebellum development and dorsal/ventral patterning of the limbs as well as apical ectodermal ridge formation. In Drosophila, the EN gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Human EN-1 and EN-2 are homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. Different mutations in the mouse homo-logs, EN-1 and EN-2, produce different developmental defects that frequently are lethal. EN-1 is highly expressed by essentially all dopaminergic neurons in the substantia nigra and ventral tegmentum. EN-1 and EN-2 regulate expres-sion of a-synuclein, a gene that is genetically linked to Parkinson?s disease.

ID gène: 2019

UniProt: Q05925

Pathways: Dopaminergic Neurogenesis