NUMBL anticorps (AA 75-120) (HRP)

N° du produit ABIN1412312

L’anticorps Lapin Polyclonal anti-NUMBL a été validé pour WB, ELISA, IHC (p) et IHC (fro). Il convient pour détecter NUMBL dans des échantillons de Humain.

Aperçu rapide pour NUMBL anticorps (AA 75-120) (HRP) (ABIN1412312)

Antigène: NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUMBL est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-NUMBL anticorps (HRP)

Épitope: AA 75-120

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human NUMBL

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur NUMBL

Antigène: NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))

Autre désignation: NUMBL

Sujet:

Synonyms: CAG 3A, CAG3A, CTG 3a, CTG3a, NBL, NUMB Drosophilia Homolog Like, Numb homolog Drosophila like, Numb homolog like, Numb like protein, NUMB R, Numb-like protein, Numb-R, Numb-related protein, NUMBL, NUMBL_HUMAN, NUMBR, TNRC 23, TNRC23.

Background: In Drosophila, neuronal cell fate decisions are directed by NUMB, a signaling adapter protein with two protein-protein interaction domains, namely a phosphotyrosine-binding domain and a proline-rich SH3-binding region (PRR). The mammalian NUMB homolog plays a role in the determination of cell fate during development and binds with a variety of proteins, including Eps15, LNX1 and Notch 1. NumbL (NUMB-like protein), also known as Numb-R, NBL, CAG3A, CTG3a, NUMBLIKE or TNRC23, is a 609 amino acid cytoplasmic protein that, like NUMB, is thought to play a role in cell fate. Expressed at high levels in developing brain tissue, NumbL contains one PID (phosphotyrosine interaction domain) and plays an important role in neuronal differentiation, possibly associating with Eps15 and Notch 1. In mice, deletion of the NumbL gene is associated with early embryonic death, suggesting an essential role for NumbL in early development.

Pathways: Cell-Cell Junction Organization