GDE1 anticorps (AA 231-331) (HRP)

N° du produit ABIN1412702

L’anticorps Lapin Polyclonal anti-GDE1 a été validé pour WB, ELISA, IHC (p) et IHC (fro). Il convient pour détecter GDE1 dans des échantillons de Souris.

Aperçu rapide pour GDE1 anticorps (AA 231-331) (HRP) (ABIN1412702)

Antigène: GDE1 (Glycerophosphodiester Phosphodiesterase 1 (GDE1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GDE1 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-GDE1 anticorps (HRP)

Épitope: AA 231-331

Réactivité croisée: Souris

Homologie: Human,Rat,Dog,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human MIR16/GDE1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur GDE1

Antigène: GDE1 (Glycerophosphodiester Phosphodiesterase 1 (GDE1))

Autre désignation: MIR16/GDE1

Sujet:

Synonyms: EC 3.1.4.44, GDE1, Glycerophosphodiester phosphodiesterase 1, Membrane interacting protein of RGS16, RGS16 interacting membrane protein, GDE1_HUMAN.

Background: GDE1 is a 331 amino acid multi-pass membrane protein that localizes to both the membrane and the cytoplasm and contains one GDPD domain. Expressed in a wide variety of tissues, GDE1 uses magnesium as a cofactor to catalyze the conversion of 1-(sn-glycero-3-phospho)-1D-myo-inositol to myo-inositol and sn-glycerol 3-phosphate, an event that is modulated by G protein signaling pathways and provides a link between phosphoinositide metabolism and G protein signal transduction. The gene encoding GDE1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3 % of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.