FBXW7 anticorps (AA 501-600) (HRP)

N° du produit ABIN1416706

Détail du produit anti-FBXW7 anticorps (HRP)

Antigène: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Épitope: AA 501-600

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXW7 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Fbxw7/hCDC4

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur FBXW7

Antigène: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Autre désignation: Fbxw7 (FBXW7 Produits)

Synonymes: anticorps cdc4, anticorps AGO, anticorps CDC4, anticorps FBW6, anticorps FBW7, anticorps FBX30, anticorps FBXO30, anticorps FBXW6, anticorps SEL-10, anticorps SEL10, anticorps hAgo, anticorps hCdc4, anticorps 1110001A17Rik, anticorps Cdc4, anticorps Fbw7, anticorps Fbwd6, anticorps Fbx30, anticorps Fbxo30, anticorps Fbxw6, anticorps F-box and WD repeat domain containing 7, anticorps F-box and WD-40 domain protein 7, anticorps Fbxw7, anticorps FBXW7, anticorps fbxw7

Sujet:

Synonyms: AGO, CDC4, FBW6, FBW7, hAgo, FBX30, FBXW6, SEL10, hCdc4, FBXO30, SEL-10, F-box/WD repeat-containing protein 7, Archipelago homolog, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, FBXW7

Background: Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463).

ID gène: 55294

UniProt: Q969H0

Pathways: Signalisation Notch, EGFR Signaling Pathway