RSAD2 anticorps (HRP)

N° du produit ABIN1418098

Cet anticorps Lapin Polyclonal détecte spécifiquement RSAD2 dans IHC (p) et IHC (fro). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour RSAD2 anticorps (HRP) (ABIN1418098)

Antigène: RSAD2 (Radical S-Adenosyl Methionine Domain Containing 2 (RSAD2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RSAD2 est conjugé à/à la HRP

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-RSAD2 anticorps (HRP)

Fonction: Viperin Polyclonal Antibody, HRP Conjugated

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Viperin/RSAD2

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur RSAD2

Antigène: RSAD2 (Radical S-Adenosyl Methionine Domain Containing 2 (RSAD2))

Autre désignation: Viperin

Sujet:

Synonyms: endoplasmic reticulum-associated, interferon-inducible, cig 33, CIG 5, cig-33, CIG-5, CIG33, CIG5, Cytomegalovirus induced gene 5 protein, Cytomegalovirus-induced gene 5 protein, Radical S-adenosyl methionine domain-containing protein 2, RSAD 2, Rsad2, RSAD2_HUMAN, RSDA-2, VIG 1, vig1, Viperin, Virus inhibitory protein, virus inhibitory protein endoplasmic reticulum associated interferon inducible.

Background: RSAD2 is a 361 amino acid protein that is involved in antiviral defense against pathogens such as Hep C, Cytomegalovirus and HIV-1. Localized to the cytosolic side of the endoplasmic reticulum and relocated to the Golgi apparatus upon viral infection, RSAD2 is thought to prevent viral budding by disrupting lipid rafts at the plasma membrane and supporting the Interferon-induced antiviral state of the cell. Additionally, RSAD2 can bind to and inactivate FDPS (an enzyme that is crucial for the synthesis of cholesterol and geranylated and farnesylated proteins), thereby playing a role in lipid synthesis. Overexpression of RSAD2 leads to abnormal lipid accumulation that is associated with atherosclerosis, a chronic inflammatory disease characterized by hardened arteries.

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response