ZNRF3 anticorps (AA 120-165) (HRP)

N° du produit ABIN1418944

Cet anticorps Lapin Polyclonal détecte spécifiquement ZNRF3 dans IHC (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour ZNRF3 anticorps (AA 120-165) (HRP) (ABIN1418944)

Antigène: ZNRF3 (Zinc and Ring Finger Protein 3 (ZNRF3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZNRF3 est conjugé à/à la HRP

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-ZNRF3 anticorps (HRP)

Épitope: AA 120-165

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ZNRF3

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur ZNRF3

Antigène: ZNRF3 (Zinc and Ring Finger Protein 3 (ZNRF3))

Autre désignation: ZNRF3

Sujet:

Synonyms: RNF203, BK747E2.3, E3 ubiquitin-protein ligase ZNRF3, RING finger protein 203, Zinc/RING finger protein 3, ZNRF3, KIAA1133

Background: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.

ID gène: 84133

UniProt: Q9ULT6

Pathways: Signalisation WNT