EHMT2 anticorps (C-Term)

N° du produit ABIN1449182

L’anticorps Hamster Monoclonal anti-EHMT2 a été validé pour WB. Il convient pour détecter EHMT2 dans des échantillons de Humain et Souris.

Aperçu rapide pour EHMT2 anticorps (C-Term) (ABIN1449182)

Antigène: EHMT2 (Ankyrin Repeat-Containing Protein (EHMT2))

Reactivité: Humain, Souris

Hôte: Hamster

Clonalité: Monoclonal

Conjugué: Cet anticorp EHMT2 est non-conjugé

Application: Western Blotting (WB)

Clone: 01-01-14

Détail du produit anti-EHMT2 anticorps

Épitope: AA 621-1000, C-Term

Specificité: This antibody reacts with both the 165 kDa G9a-L isoform and the 140 kDa G9a-S isoform.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse

Purification: Protein A agarose

Immunogène: GST-mouse G9a C-terminal protein (a.a. 621-1000)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur EHMT2

Antigène: EHMT2 (Ankyrin Repeat-Containing Protein (EHMT2))

Autre désignation: BAT8

Sujet: G9a (BAT8, NG36) is a major histone methyltransferase that acts by adding a methyl group to the Lys9 amino acid on histone H3 proteins. Methylation of Lys9 on histone H3 is important for the regulation of the expression of crucial genes during embryogenesis. Methylation of Lys9 may also play a role in tumorigenesis, since deregulation of histone H3 Lys9 methylation in G9a-deficient cells induces the expression of Mage-2a, a tumor-specific protein whose function is unknown. The 165 kDa G9a protein has an unusual structure, containing 24 contiguous glutamate residues in the N-terminus and 6 contiguous copies of a 33-amino acid ankyrin repeat in the C-terminus. The presence of the ankyrin repeats suggest that G9a may be involved in intracellular protein-protein interactions. G9a is expressed in monocytic, macrophage, hepatocyte, T-cell, B-cell, epithelial, and promyelocytic cell lines.Synonyms: C6orf30, EHMT2, Euchromatic histone-lysine N-methyltransferase 2, H3 lysine-9 specific 3, H3-K9-HMTase 3, HLA-B-associated transcript 8, Histone H3-K9 methyltransferase 3, Histone-lysine N-methyltransferase, KMT1C, Lysine N-methyltransferase 1C, NG36, Protein G9A

ID gène: 110147

NCBI Accession: NP_665829

UniProt: Q9Z148