Retinoblastoma 1 anticorps (pThr821)

N° du produit ABIN1449258

Cet anticorps anti-Retinoblastoma 1 est un anticorps Souris Monoclonal détectant Retinoblastoma 1 dans WB. Adapté pour Humain.

Aperçu rapide pour Retinoblastoma 1 anticorps (pThr821) (ABIN1449258)

Antigène: Retinoblastoma 1 (RB1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Retinoblastoma 1 est non-conjugé

Application: Western Blotting (WB)

Clone: 24A7

Détail du produit anti-Retinoblastoma 1 anticorps

Épitope: pThr821

Specificité: This antibody specifically recognizes human Rb with phosphorylated at Thr821.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Upon receipt, store (in aliqouts) at -20 °C.

Détails sur Retinoblastoma 1

Antigène: Retinoblastoma 1 (RB1)

Autre désignation: Retinoblastoma-Associated Protein / RB1

Sujet: Retinoblastoma protein (Rb), the tumor suppressor product of the retinoblastoma susceptibility gene, is a 110 kDa protein that functions as a negative regulator of the cell cycle by arresting cells in the G 1 phase and halting inappropriate cell proliferation (Ref1 . At the transcriptional level, Rb protein exerts its growth suppressive function by binding to transcription factors including E2F1, PU.1, ATF2, UBF, Elf-1 and c-Abl (Ref 2-4 . Loss of Rb function leads to uncontrolled cell growth and tumor development and is found in all retinoblastomas and in a variety of other human malignancies. The ability of Rb protein to inhibit the transcription and the cell cycle progression is inactivated by phosphorylation, which is catalyzed by the cyclin-d ependent protein kinases.Synonyms: OSRC, Rb, Retinoblastoma 1, p105-Rb, pRb, pp110

ID gène: 5925

NCBI Accession: NP_000312

UniProt: P06400

Pathways: Cycle Cellulaire, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy