Transferrin Receptor anticorps

N° du produit ABIN1449271

Cet anticorps Souris Monoclonal détecte spécifiquement Transferrin Receptor dans FACS et IP. Il présente une réactivité envers Humain.

Aperçu rapide pour Transferrin Receptor anticorps (ABIN1449271)

Antigène: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Transferrin Receptor est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP)

Clone: WK7

Détail du produit anti-Transferrin Receptor anticorps

Purification: Protein A agarose

Immunogène: Human myeloma cell line (RPMI8226)

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Upon receipt, store (in aliqouts) at -20 °C.

Détails sur Transferrin Receptor

Antigène: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Autre désignation: CD71 / TFRC

Sujet: CD71 is a homodimeric type II transmembrane glycoprotein consisting of two disulfide-bonded 95 kDa chains. CD71 is the transferrin receptor (TfR). The CD71 binds iron saturated holo-transferrin on the cell surface and is internalized and transported to early sorting endosomes, where the complexed iron is rapidly separated from transferrin. Subsequently, the CD71-transferrin complex accumulates within recycling endosomes and then recycles to the plasma membrane. On the cell surface, iron-free apotransferrin has negligible affinity for CD71, and is released from the cell, ready to begin a new cycle. CD 71 is expressed on activated B and T cells, macrophages, reticulocytes, erythroid precursors, and malignant tissues. Particularly high expression of CD71 is reported in the reticulocytes and erythroid series, reflecting the requirement for iron in hemoglobin. CD71 expression is upregulated on immature proliferating cells and low levels on resting mature lymphocytes. In addition to this general function, CD71 appears to play a costimulatory role in T cell activation and receptor for IgA1 antibodies.Synonyms: TfR1, Transferrin receptor protein 1, p90

ID gène: 9606

UniProt: P02786

Pathways: Transition Metal Ion Homeostasis