Transferrin Receptor anticorps

N° du produit ABIN94221

Cité dans 1 publication. Cet anticorps anti-Transferrin Receptor Monoclonal Souris (Clone MEM-75) (ABIN94221) détecte spécifiquement Transferrin Receptor dans FACS, IP et ICC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Transferrin Receptor anticorps (ABIN94221)

Antigène: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Transferrin Receptor est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Clone: MEM-75

Détail du produit anti-Transferrin Receptor anticorps

Fonction: Anti-Hu CD71 Purified

Réactivité croisée (Details): Human

Attributs du produit: The antibody MEM-75 reacts with an extracellular epitope of CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages and erythroid precursors, it is lost on resting blood leukocytes. The antibody MEM-75 does not block binding of transferrin to the receptor.

Purification: Purified by protein-A affinity chromatography.

Pureté: > 98 % (by SDS-PAGE)

Immunogène: NALM-6 human pre-B cell line

Isotype: IgG1, kappa

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 0.5-4 μg/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-Transferrin Receptor (ABIN94221)

Beck, Balogh, Kis, Izsépi, Cervenak, László, Bíró, Liliom, Mocsár, Vámosi, Füst, Matko: "New cholesterol-specific antibodies remodel HIV-1 target cells' surface and inhibit their in vitro virus production." dans: Journal of lipid research, Vol. 51, Issue 2, pp. 286-96, (2010) (PubMed).

Détails sur Transferrin Receptor

Antigène: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Autre désignation: CD71

Sujet: Transferrin receptor,CD71 (transferrin receptor) is a type II transmembrane glycoprotein expressed as homodimer in erythroid blood cell line and in activated leukocytes. Upon binding of holotransferrin (complex of transferrin and iron ions), CD71 is internalized by clathrin-mediated endocytosis. Acidification of endosomes by vesicular membrane proton pumps leads to dissociation of iron ions, whereas transferrin (apotransferrin) remains associated with CD71 and recycles to the cell surface, where it is released upon exposure to normal pH . CD71 is also involved in uptake of non-transferrin bound iron.,TfR1, TfR, TR, Trfr, T9, p90, TFRC

ID gène: 7037

UniProt: P02786

Pathways: Transition Metal Ion Homeostasis