SCIMP anticorps

N° du produit ABIN1449307

Détail du produit anti-SCIMP anticorps

Antigène: SCIMP (SLP Adaptor and CSK Interacting Membrane Protein (SCIMP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SCIMP est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein-A affinity chromatography

Pureté: > 95 % pure by SDS-PAGE

Immunogène: Recombinant intracellular part of human SCIMP

Clone: NVL-07

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), approx. pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur SCIMP

Antigène: SCIMP (SLP Adaptor and CSK Interacting Membrane Protein (SCIMP))

Autre désignation: SCIMP (SCIMP Produits)

Synonymes: anticorps C17orf87, anticorps UNQ5783, anticorps A430084P05Rik, anticorps SLP adaptor and CSK interacting membrane protein, anticorps SCIMP, anticorps Scimp

Sujet: SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.Synonyms: SLP adaptor and Csk interacting membrane protein

ID gène: 388325

NCBI Accession: NP_996986

UniProt: Q6UWF3