SHANK3 anticorps (Middle Region)

N° du produit ABIN1449931

Cet anticorps Lapin Polyclonal détecte spécifiquement SHANK3 dans WB, IF, IHC (p) et EIA. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour SHANK3 anticorps (Middle Region) (ABIN1449931)

Antigène: SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SHANK3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-SHANK3 anticorps

Épitope: Middle Region

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity chromatography purified via peptide column

Immunogène: 19 amino acid synthetic peptide near the center of human SHANK3

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur SHANK3

Antigène: SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))

Autre désignation: SHANK3

Sujet: SH3 and multiple ankyrin repeat domains 3 (SHANK3), a member of the Shank gene family, plays a role in synapse formation and dendritic spine maturation. Shank proteins (Shank 1-3) containing PDZ domains are scaffold proteins of the postsynaptic density (PSD) that connect neurotransmitter receptors and ion channels proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development. Mutations of SHANK3 are a cause of autism spectrum disorder (ASD) and the neurological symptoms of 22q13.3 deletion syndrome.Synonyms: PSAP2, ProSAP2, Proline-rich synapse-associated protein 2, SH3 and multiple ankyrin repeat domains 3, SPANK-2

NCBI Accession: NP_001073889

Pathways: Synaptic Membrane, Tube Formation, Regulation of long-term Neuronal Synaptic Plasticity