DELE1/KIAA0141 anticorps (N-Term)

N° du produit ABIN1449949

Détail du produit anti-DELE1/KIAA0141 anticorps

Antigène: DELE1/KIAA0141 (DELE1) (DAP3 Binding Cell Death Enhancer 1 (DELE1))

Épitope: N-Term

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DELE1/KIAA0141 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogène: 18 amino acid synthetic peptide near the amino terminus of Human DELE

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur DELE1/KIAA0141

Antigène: DELE1/KIAA0141 (DELE1) (DAP3 Binding Cell Death Enhancer 1 (DELE1))

Autre désignation: KIAA0141 (DELE1 Produits)

Synonymes: anticorps KIAA0141, anticorps MGC139304, anticorps DELE, anticorps 2700004E22Rik, anticorps Dele, anticorps Kiaa0141, anticorps KIAA0141, anticorps KIAA0141 ortholog, anticorps RIKEN cDNA 0610009O20 gene, anticorps SEL1 domain containing protein RGD735029, anticorps KIAA0141, anticorps 0610009O20Rik, anticorps RGD735029

Sujet: DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-alpha and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-alpha, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.

ID gène: 9812

NCBI Accession: NP_055588