DISP2 anticorps (N-Term)

N° du produit ABIN1449961

Détail du produit anti-DISP2 anticorps

Antigène: DISP2 (Dispatched Homolog 2 (DISP2))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DISP2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogène: 18 amino acid synthetic peptide near the amino terminus of Human DISP2

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur DISP2

Antigène: DISP2 (Dispatched Homolog 2 (DISP2))

Autre désignation: DISP2 / DISPB (DISP2 Produits)

Synonymes: anticorps DISP2, anticorps DISPB, anticorps HsT16908, anticorps AI840597, anticorps B230210L08Rik, anticorps DispB, anticorps mKIAA1742, anticorps dispatched RND transporter family member 2, anticorps dispatched RND tramsporter family member 2, anticorps dispatched homolog 2 (Drosophila), anticorps DISP2, anticorps Disp2

Sujet: DISP2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants.Synonyms: KIAA1742, Protein dispatched homolog 2

ID gène: 85455

UniProt: A7MBM2

Pathways: Signalisation Hedgehog