TAB3 anticorps (N-Term)
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- Antigène Voir toutes TAB3 Anticorps
- TAB3 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 3 (TAB3))
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Épitope
- N-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TAB3 est non-conjugé
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Purification
- Affinity chromatography purified via peptide column
- Immunogène
- 13 amino acid synthetic peptide near the amino terminus of Human TAB3
- Isotype
- IgG
- Top Product
- Discover our top product TAB3 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 0.02 % Sodium Azide as preservative
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- TAB3 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 3 (TAB3))
- Autre désignation
- TAB3 / MAP3K7IP3 (TAB3 Produits)
- Synonymes
- anticorps MAP3K7IP3, anticorps NAP1, anticorps 4921526G09Rik, anticorps Map3k7ip3, anticorps mKIAA4135, anticorps map3k7ip3, anticorps nap1, anticorps tab3, anticorps tab3-a, anticorps tab3-b, anticorps map3k7ip3l, anticorps si:ch211-232d19.8, anticorps si:dkey-30h22.6, anticorps TGF-beta activated kinase 1 and MAP3K7 binding protein 3, anticorps TGF-beta activated kinase 1/MAP3K7 binding protein 3, anticorps TGF-beta activated kinase 1/MAP3K7 binding protein 3 S homeolog, anticorps TAB3, anticorps Tab3, anticorps tab3.S, anticorps tab3
- Sujet
- TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1, upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.Synonyms: Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1-binding protein 3
- ID gène
- 257397
- NCBI Accession
- NP_690000
- Pathways
- Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
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