CBX4 anticorps (N-Term)
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- Antigène Voir toutes CBX4 Anticorps
- CBX4 (Chromobox Homolog 4 (CBX4))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CBX4 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
- Purification
- Affinity chromatography purified via peptide column
- Immunogène
- A 17 amino acid synthetic peptide near the amino terminus of Human CBX4
- Isotype
- IgG
- Top Product
- Discover our top product CBX4 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 0.02 % Sodium Azide as preservative
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- CBX4 (Chromobox Homolog 4 (CBX4))
- Autre désignation
- CBX4 / PC2 (CBX4 Produits)
- Synonymes
- anticorps MPc2, anticorps PC2, anticorps NBP16, anticorps XPolycomb, anticorps cbx4-a, anticorps im:6911625, anticorps zgc:158588, anticorps chromobox 4, anticorps chromobox 4 S homeolog, anticorps chromobox homolog 4, anticorps chromobox homolog 4 (Pc class homolog, Drosophila), anticorps CBX4, anticorps Cbx4, anticorps cbx4.S, anticorps cbx4
- Sujet
- Polycomb group (PcG) proteins are chromatin-associated proteins which are important for embryonic and adult stem cell self-renewal and maintenance. At least two distinct human PcG complexes have been identified. Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1 and RING domain-containing proteins (RING1, RING2 and BMI1). CBX4 (Chromobox protein homolog 4 or PC2), which functions as a transcriptional suppressor, is a candidate of KyoT2-binding proteins. It is a E3 SUMO-protein ligase which facilitates SUMO1 conjugation. Depletion of CBX4 results in decreased cellular resistance to ionizing radiation. CBX4 is directly involved in the cellular response to DNA damage.Synonyms: Chromobox protein homolog 4, E3 SUMO-protein ligase CBX4, Polycomb 2 homolog
- Poids moléculaire
- 62 kDa
- ID gène
- 8535
- NCBI Accession
- NP_003646
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