RGS22 anticorps (N-Term)

N° du produit ABIN1449995

L’anticorps anti-RGS22 Polyclonal Lapin est utilisé pour la détection de RGS22 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IF et EIA.

Aperçu rapide pour RGS22 anticorps (N-Term) (ABIN1449995)

Antigène: RGS22 (Regulator of G-Protein Signaling 22 (RGS22))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RGS22 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-RGS22 anticorps

Épitope: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogène: A 19 amino acid synthetic peptide near the amino terminus of Human RGS22

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur RGS22

Antigène: RGS22 (Regulator of G-Protein Signaling 22 (RGS22))

Autre désignation: RGS22

Sujet: Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit (1,2). RGS22 is a recently identified member of this family that localizes to the testis and can interact with guanine nucleotide binding proteins alpha 11, 12, and 13 (GNA11, GNA12, and GNA13). While RGS22 has been postulated to play a role in spermiogenesis in the testis, it is also expressed in several cancer cell lines with an epithelial origin and associated with cancer metastasis. Its overexpression in a highly metastatic cancer causes a decrease in cell migration and a reduction of the invasive potential of the cells, suggesting that RGS22 may be a potential prognostic biomarker for metastasis.Synonyms: Regulator of G-protein signaling 22

Poids moléculaire: 139 kDa

ID gène: 26166

NCBI Accession: NP_056483

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling