C9ORF116 anticorps (N-Term)

N° du produit ABIN1450123

Détail du produit anti-C9ORF116 anticorps

Antigène: C9ORF116 (Chromosome 9 Open Reading Frame 116 (C9ORF116))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp C9ORF116 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunofluorescence (IF)

Purification: Affinity chromatography purified via peptide column

Immunogène: 16 amino acid synthetic peptide near the amino terminus of Human PIERCE1

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur C9ORF116

Antigène: C9ORF116 (Chromosome 9 Open Reading Frame 116 (C9ORF116))

Autre désignation: C9orf116 (C9ORF116 Produits)

Synonymes: anticorps PIERCE1, anticorps RbEST47, anticorps Rbest47, anticorps chromosome 9 open reading frame 116, anticorps RIKEN cDNA 1700007K13 gene, anticorps chromosome ssa24 open reading frame, human C9orf116, anticorps chromosome 11 open reading frame, human C9orf116, anticorps C9orf116, anticorps 1700007K13Rik, anticorps cssa24h9orf116, anticorps C11H9orf116

Sujet: PIERCE1, also known as C9orf116, is an important p53 target gene contributing to normal DNA damage response and may play crucial roles in maintaining genomic integrity against genotoxic stresses, including UVC irradiation (1,2). PIERCE1 exists as two alternatively spliced isoforms and is predominantly expressed in human small cell lung cancer (3-4). PIERCE1 knockdown induces down-regulation of proapoptotic genes including Ei24, Apaf1 and PTEN, suggesting that PIERCE1 is a proapoptotic gene. It is helpful for in-depth understanding of p53 pathways and the design of new cancer therapies (1-3).Synonyms: Pierce1, p53-induced expression in RB-null cells protein 1

ID gène: 138162

NCBI Accession: NP_001041730