HHATL anticorps (N-Term)

N° du produit ABIN1450142

L’anticorps anti-HHATL Polyclonal Lapin est utilisé pour la détection de HHATL dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IHC (p), IF et EIA.

Aperçu rapide pour HHATL anticorps (N-Term) (ABIN1450142)

Antigène: HHATL (Hedgehog Acyltransferase-Like (HHATL))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HHATL est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-HHATL anticorps

Épitope: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogène: 19 amino acid synthetic peptide near the amino terminus of Human HHATL

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur HHATL

Antigène: HHATL (Hedgehog Acyltransferase-Like (HHATL))

Autre désignation: GUP1 / HHATL

Sujet: The Protein-cysteine N-palmitoyltransferase HHAT-like protein (HHATL), also known at the mammalian glycerol uptake/transporter 1 (Gup1) is a homolog of the S. cerevisiae Gup1. It is an endoplasmic reticulum (ER) membrane protein that co-localizes with the mammalian hedgehog acyltransferse Skn and interferes with its N-terminal palmitoylation of Sonic hedgehog (SHH), suggesting that HHATL acts as a negative regulator for N-terminal palmitoylation of SHH. HHATL is highly expressed in normal skin, but becomes down-regulated in skin squamous cell carcinoma, suggesting it may play a role in its development .Synonyms: C3orf3, Glycerol uptake/transporter homolog, Hedgehog acyltransferase-like protein, KIAA1173, Protein-cysteine N-palmitoyltransferase HHAT-like protein

ID gène: 57467

NCBI Accession: NP_065758

Pathways: Signalisation Hedgehog