Aggrecan anticorps

N° du produit ABIN1450192

Cet anticorps Souris Monoclonal détecte spécifiquement Aggrecan dans WB, IP, IHC (p), IHC (fro) et EIA. Il présente une réactivité envers Humain et Boeuf (Vache) et a été mentionné dans 1 publication.

Aperçu rapide pour Aggrecan anticorps (ABIN1450192)

Antigène: Aggrecan (ACAN)

Reactivité: Humain, Boeuf (Vache)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Aggrecan est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Clone: HAG7D4 (7D4)

Détail du produit anti-Aggrecan anticorps

Réactivité croisée (Details): Species reactivity (tested):Human and Bovine.

Purification: Prepared by Affinity Chromatography on Protein G from Tissue Culture Supernatant

Immunogène: Purified Human articular cartilage Aggrecan. Remarks: Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the lyophilized product at 2-8 °C. Following reconstitution store (in aliquots) at -20 °C.

Références pour anticorps anti-Aggrecan (ABIN1450192)

Anders, Mollenhauer, Beberhold, Kinne, Venbrocks: "Gelatin-based haemostyptic Spongostan as a possible three-dimensional scaffold for a chondrocyte matrix?: an experimental study with bovine chondrocytes." dans: The Journal of bone and joint surgery. British volume, Vol. 91, Issue 3, pp. 409-16, (2009) (PubMed).

Détails sur Aggrecan

Antigène: Aggrecan (ACAN)

Autre désignation: Aggrecan

Sujet: Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.Synonyms: ACAN, AGC1, CSPG1, Cartilage-specific proteoglycan core protein, Chondroitin sulfate proteoglycan core protein 1, MSK16

ID gène: 176, 9606

UniProt: P16112

Pathways: Glycosaminoglycan Metabolic Process, Dicarboxylic Acid Transport