RAD51 anticorps (pThr309)

N° du produit ABIN1450500

Cet anticorps anti-RAD51 Polyclonal Lapin (ABIN1450500) détecte spécifiquement RAD51 dans WB, IHC, ELISA et IF. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour RAD51 anticorps (pThr309) (ABIN1450500)

Antigène: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAD51 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-RAD51 anticorps

Épitope: AA 275-324, pThr309

Fonction: Rad51 (phospho Thr309) Antibody

Specificité: Phospho-Rad51 (T309) Polyclonal Antibody detects endogenous levels of Rad51 protein only when phosphorylated at T309.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: The antiserum was produced against synthesized peptide derived from human RAD51 around the phosphorylation site of Thr309. AA range:275-324

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:5000. IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur RAD51

Antigène: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Autre désignation: RAD51

Sujet:

Synonyms: RAD51, RAD51A, RECA, DNA repair protein RAD51 homolog 1, HsRAD51, hRAD51, RAD51 homolog A

Background: The protein encoded byThis gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009],

Gene Name: RAD51

Protein Name: DNA repair protein RAD51 homolog 1

Poids moléculaire: 36 kDa

ID gène: 5888

OMIM: 114480

UniProt: Q06609

Pathways: Réparation de l'ADN