Complement Factor I anticorps (AA 441-490)

N° du produit ABIN1451187

Cet anticorps anti-Complement Factor I Polyclonal Lapin (ABIN1451187) détecte spécifiquement Complement Factor I dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Complement Factor I anticorps (AA 441-490) (ABIN1451187)

Antigène: Complement Factor I (CFI)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Complement Factor I est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Complement Factor I anticorps

Épitope: AA 441-490

Fonction: Factor I Antibody

Specificité: Factor I Polyclonal Antibody detects endogenous levels of Factor I protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: The antiserum was produced against synthesized peptide derived from human CFI. AA range:441-490

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur Complement Factor I

Antigène: Complement Factor I (CFI)

Autre désignation: CFI

Sujet:

Synonyms: CFI, IF, Complement factor I, C3B/C4B inactivator

Background: This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. [provided by Ref

Gene Name: CFI

Protein Name: Complement factor I

Poids moléculaire: 65 kDa

ID gène: 3426

OMIM: 217030

UniProt: P05156

Pathways: Système du Complément